The character with the most episodes in "Melrose Place," Dr. Michael Mancini, appeared in every season and was the only character to do so. Dr. Mancini underwent many changes, such as transitioning from a lovable doctor to an adulterous villain. Since the show wrapped, Thomas Calabro has remained largely inactive, never appearing in more than one episode of any other TV show.
After a guest spot in season one, the character of Amanda Woodward was promoted to series regular status in season two. An ambitious ad executive, Amanda was one of the more popular characters and one that helped boost ratings. Locklear also appeared in the 2009 reboot of the show and had a career in TV, including stints on "Spin City" and "Franklin and Bash."
Sydney Andrews was the younger sister of Jane Mancini, who had a turbulent relationship with her sister's husband among other issues. Leighton reprised her original role on the "Melrose Place" reboot in 2009. Since then, Leighton's face is recognized as Ashley Maron, the mother of one of the central four characters on the hit ABC Family series "Pretty Little Liars."
Initially not a focal point character, Matt Fielding worked as an openly gay social worker in Los Angeles, As the show progressed, the character became more focused on dealing with issues of discrimination towards homosexuals. Actor Doug Savant moved on from one primetime soap opera to another with his 176-episode run on "Desperate Housewives."
Another character that initially started as a simple recurring role, Dr. Kimberly Shaw was promoted to regular by the end of the second season. Working with Dr. Mancini, Dr. Shaw became the other woman that caused the disintegration of the Mancini marriage. Marcia Cross would continue to work with Doug Savant as they both moved on to "Desperate Housewives."
Allison Parker played a role in the crossover continuity between "Beverly Hills 90210" and "Melrose Place." Serving as a roommate for Billy Campbell, Allison appeared on 160 episodes of the primetime soap opera. Television continues to be Courtney Thorne-Smith's major medium with the biggest role being her 182-episode run of "According to Jim."
Jake Hanson was the Melrose Place apartment complex's resident motorcycle enthusiast as well as manual laborer. Jake actually married Allison Parker, although the two separated by the end of the show. Actor Grant Show remains a TV staple, earning roles in "Burn Notice" and "Private Practice."
Jane Mancini was the wife of Dr. Mancini and a budding fashion designer. The relationship between Jane and Michael served as a focal point for the early seasons, including the crumbling of the relationship based on the infidelities of Dr. Mancini. After "Melrose Place," Josie Bissett moved right on to "The Secret Life of the American Teenager" for a 90-episode run.
As one of the tenants of the Melrose Place apartment complex, Billy Campbell aspired to being a writer, although he was often found struggling, both with his career and his independence from his parents. Since the show wrapped, Andrew Shue has remained largely dormant, appearing in only one credited role in the decade after "Melrose Place."
"Melrose Place" re-established the genre of primetime soap opera in the '90s. It propelled the careers of several stars, including Heather Locklear and Marcia Cross.